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Figure 4 | Molecular Cancer

Figure 4

From: ErbB2 enhances mammary tumorigenesis, oncogene-independent recurrence and metastasis in a model of IGF-IR-mediated mammary tumorigenesis

Figure 4

ErbB2 overexpression enhanced proliferation in vivo shortly after injection. Immunohistochemistry for Ki67 in mammary glands injected with RM11A+Dox (a, c) and RM11A+Dox/ErbB2 (b, d) cells 4 (a, b) or 14 (c, d) days after cell injection into the mammary fat pad. Quantification of Ki67 staining revealed a significant increase in proliferation at day 4 but not day 14 in the RM11A+Dox/ErbB2 tumors compared to RM11A+Dox tumors (e). Scale bars: 100 μm.

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Molecular Cancer

ISSN: 1476-4598