Figure 4

Growth of 4TX12 tumors in immunodeficient and cell subset-depleted mice. A-B) SCID mice were injected i.m.f.p. with 1 × 10⁵ cells. Tumor volume (mean ± SEM; A) and final tumor weight (mean ± SEM; B) were measured (n = 5). C-D) BALB/c mice were injected i.m.f.p. with 1 × 10⁵ cells and treated with anti-CD4, anti-CD8, control IgG or PBS as described in Materials and Methods. Data points represent mean tumor volume ± SEM in mice depleted of (C) CD4⁺ cells, n = 8, and (D) CD8⁺ cells, n = 6; *, p < 0.05; ns, not significant compared to 4TX12 tumors in mice treated with control IgG (t test).