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Figure 4 | Molecular Cancer

Figure 4

From: Down-regulation of the Nucleotide Excision Repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells

Figure 4

Studies in parental and nemorubicin resistant human HCT116 cells. Panel A. Inhibition of colony formation induced by nemorubicin in HCT116 parental cells (black circle) or resistant clones M1 (black square), M7 (white circle), M12 (black triangle), M14 (white square), M23 (white triangle). Results are reported as percentages of growth inhibition relative to untreated cells and are the mean and SD of at least three replicates. Panel B. Western blot analysis for the expression of NER-belonging genes ERCC1, XPA and XPG in parental and nemorubicin-resistant cells. Response of HCT116 parental cells (black circle) or resistant clones M1 (black square), M7 (white circle), M12 (black triangle), M14 (white square), M23 (white triangle) to UV treatment (Panel C) or γ-rays (Panel D). Results are reported as percentages of growth inhibition relative to untreated cells and are the mean and SD of at least three replicates.

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Molecular Cancer

ISSN: 1476-4598