Figure 2
From: Epigenetic regulation of CpG promoter methylation in invasive prostate cancer cells
Oncomine analysis of overlapping targets methylated in both LNCaP and DU145 cells. Isolated targets from the methylation arrays overlapping in LNCaP and DU145 cells were analyzed in Oncomine 4.2 (Ann Arbor, MI). The heat map represents raw data from the Varambally over-expression in prostate cancer analysis comparing primary tissue and metastatic tissue [17]. Expression is in terms of normalized over-expression units. The P-value represents a student's t-test comparing primary and metastatic expression and the gene ID is provided. Genes of interest included Sox1 (p = 0.024) since it has high homology to the stem cell gene Sox2 and albeit demonstrating significance, Bmx (p = 0.294), since it has previously been implicated in prostate cancer regulation.