Table 1 Effect of gefitinib and rofecoxib combination in MM cell lines according to the Chou and Talalay method
From: Synergistic effect of gefitinib and rofecoxib in mesothelioma cells
Cell Lines | Schedule | FA | CI | Effect |
|---|---|---|---|---|
Ist-Mes-2 | 12 μM R+12.5 μM G | 0.59 | 0.74 | moderately synergistic |
|  | 12 μM R+25 μM G | 0.78 | 0.55 | Synergistic |
|  | 25 μM G+4 μM R | 0.75 | 0.48 | Synergistic |
|  | 25 μM G+36 μM R | 0.81 | 0.8 | moderately synergistic |
Ist-Mes-1 | 12 μM R+12.5 μM G | 0.27 | > 1.1 | Antagonistic |
|  | 12 μM R+25 μM G | 0.20 | > 1.1 | Antagonistic |
|  | 25 μM G+4 μM R | 0.35 | > 1.1 | Antagonistic |
|  | 25 μM G+36 μM R | 0.17 | > 1.1 | Antagonistic |
MPP89 | 12 μM R+12.5 μM G | 0.22 | > 1.1 | Antagonistic |
|  | 12 μM R+25 μM G | 0.16 | > 1.1 | Antagonistic |
|  | 25 μM G+4 μM R | 0.60 | > 1.1 | Antagonistic |
|  | 25 μM G+36 μM R | 0.45 | > 1.1 | Antagonistic |