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Table 1 Effect of gefitinib and rofecoxib combination in MM cell lines according to the Chou and Talalay method

From: Synergistic effect of gefitinib and rofecoxib in mesothelioma cells

Cell Lines Schedule FA CI Effect
Ist-Mes-2 12 μM R+12.5 μM G 0.59 0.74 moderately synergistic
  12 μM R+25 μM G 0.78 0.55 Synergistic
  25 μM G+4 μM R 0.75 0.48 Synergistic
  25 μM G+36 μM R 0.81 0.8 moderately synergistic
Ist-Mes-1 12 μM R+12.5 μM G 0.27 > 1.1 Antagonistic
  12 μM R+25 μM G 0.20 > 1.1 Antagonistic
  25 μM G+4 μM R 0.35 > 1.1 Antagonistic
  25 μM G+36 μM R 0.17 > 1.1 Antagonistic
MPP89 12 μM R+12.5 μM G 0.22 > 1.1 Antagonistic
  12 μM R+25 μM G 0.16 > 1.1 Antagonistic
  25 μM G+4 μM R 0.60 > 1.1 Antagonistic
  25 μM G+36 μM R 0.45 > 1.1 Antagonistic
  1. Note: G indicates gefitinib, R indicates rofecoxib, FA denotes the fraction of growth affect of drug-treated cells compared with control cells and CI denotes the combination index.