Skip to main content
Figure 5 | Molecular Cancer

Figure 5

From: Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells

Figure 5

Schematic representation of a mechanism of EGCG-induced ERα reactivation in ERα-negative breast cancer cells. In this model, EGCG and TSA can affect chromatin modifications as well as the binding alteration of a transcription repressor complex, Rb/p130-E2F4/5-HDAC1-DNMT1-SUV39H1, to the ERα promoter, resulting in ERα reactivation in ERα-negative breast cancer cells.

Back to article page

Molecular Cancer

ISSN: 1476-4598