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Figure 1 | Molecular Cancer

Figure 1

From: Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness

Figure 1

BRG1 is highly expressed in patient derived melanomas and metastatic melanoma cell lines. A. Tissue Scan Melanoma qPCR Arrays (Origene) containing cDNAs from patient derived normal skin, stage III melanomas, and stage IV melanomas were subjected to qRT-PCR with BRG1 specific primers. BRG1 levels were normalized to β-actin. The results were averaged from values obtained by performing three PCR arrays. B. Western blot comparing BRG1 levels in two invasive melanoma cell lines (A375SM and WM-266-4) and human epidermal melanocytes with that in BRG1 deficient SK-MEL5 cells, SK-MEL5 cells reconstituted with empty vector (EV), and BRG1 reconstituted SK-MEL5 cells. Total cell lysate was loaded. Tubulin is a loading control.

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Molecular Cancer

ISSN: 1476-4598