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Figure 3 | Molecular Cancer

Figure 3

From: Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness

Figure 3

BRG1 promotes E-cadherin expression but compromises E-cadherin localization to the cell junction in SK-MEL5 cells. A. Detection of E-cadherin (CDH1) and CTNND2 protein expression by Western blotting. Tubulin is a loading control. B. Cells were stained with control IgG or an antibody to E-cadherin and FITC labeled secondary antibody. E-cadherin at the cell surface was quantified by FACS analysis. Significantly less E-cadherin was localized to the cell surface in SK-MEL5 +BRG1 cells compared to control SK-MEL5 cells (p < 0.05). C. E-cadherin staining of representative control SK-MEL5 cells and BRG1 expressing SK-MEL5 cells by immunofluorescence.

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Molecular Cancer

ISSN: 1476-4598