Figure 1

Relationship between MLL expression and GC resistance in T-ALL Cell Lines. (A) Normalized MLL mRNA expression across the T-ALL cell line panel as measured by qRT-PCR (bars) and IC50 values for MPRED (open circles) and DEX (closed squares); (B) Schematic of MLL mRNA indicating the target location of five microarray probes (indicated by solid lines) and protein domains within the coding region: MBR, Major Break Region; RD, Repression Domain; TAD, Transactivation Domain; PC, site of proteolytic cleavage. Correlation of expression level vs. cell line IC50 for DEX (D) and MPRED (M) is indicated for each probe (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001).