ADP-ribose polymer - a novel and general biomarker of human cancers of head & neck, breast, and cervix

Table 4 Influence of selected etiological factors on poly-ADP-ribose adduct in cancer patients

Cancer patients (Cases)	Category	Number of cases (n)	Poly-ADP-ribose adduct level (AU) (Mean ± SD)	P
Gender	Male	49	8161 ± 643.6	0.0673
	Female	63	7982 ± 748.2
Tobacco	Yes (+)	48	7840 ± 543	0.0033*
	No (-)	64	8232 ± 771
Alcohol	Yes (+)	34	7699 ± 518.1	0.0001*
	No (-)	78	8223 ± 718.9
Betel nut	Yes (+)	68	7963 ± 628.3	0.0935
	No (-)	44	8220 ± 791.9
Diet	Yes (+)	56	8110 ± 707.8	0.6902
	No (-)	56	8010 ± 709.2

Table showing the effect of selected cancer-relevant etiological factors on the level of total poly-ADP-ribose adduct of PBL proteins (mean ± SD) in cancer patients (cases). A Mann-Whitney rank sum test was performed to analyze the effect of the etiological factors. Highly or moderately significant reductions of the total poly-ADP-ribose adduct of PBL proteins were observed in patients exposed to alcohol (compared to alcohol minus patients) and tobacco (compared to tobacco minus patients), respectively. Interestingly, gender, BN and diet did not seem to influence the poly-ADP-ribose adduct level in these patients (* - statistically significant).

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