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Figure 6 | Molecular Cancer

Figure 6

From: The two most common histological subtypes of malignant germ cell tumour are distinguished by global microRNA profiles, associated with differential transcription factor expression

Figure 6

Putative transcription factor binding sites in the miR-302 promoter region. A) Schematic of the miR-302 genomic locus at chromosome band 4q25, adapted from [18], showing the 2 kb region upstream of the last microRNA in the cluster, miR-367. The miR-302 cluster itself is 684bp in length. Potential binding sites for four transcription factors (GATA6, GATA3, TCF7L2 and MAF) are shown by the coloured triangles. B) The consensus sequence binding motifs for the four transcription factors with predicted binding sites in the 10 kb region upstream of the miR-302 cluster. Nucleotide position is displayed horizontally and information content vertically. The relative height of the individual nucleotides represents the relative frequency of each nucleotide at that position, based on multiple sequence alignments obtained from known gene targets. Although the GATA6 binding motif is 10nt in length, the 10th base has an extremely low information content and is not visible in the schematic.

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Molecular Cancer

ISSN: 1476-4598