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Figure 2 | Molecular Cancer

Figure 2

From: Investigation of DNA damage response and apoptotic gene methylation pattern in sporadic breast tumors using high throughput quantitative DNA methylation analysis technology

Figure 2

Binned CpG units and differential methylation. (A) CpG sites/units binned on the basis of their average methylation value. Each bin contained amplicon within a 5% range of methylation values. Lower bins contained more CpGs in the set of 81 normal breast tissue (B) Differential methylation in normal vs. tumor samples across different mean methylation groups based on binning of normal samples. P value was obtained using Mann-Whitney U test for two groups. Note: X - Axis represents groups of mean methylation obtained in normal tissue samples for the study population. For each of the 139 CpG units, the methylation values for the 81 normal tissues were added to obtain mean methylation values. These were then divided into groups of 0% - 5%, 5% - 10%, 10% - 15%, 15% - 20%, 20% - 25% and 25% - 30%.

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Molecular Cancer

ISSN: 1476-4598