Table 4 Correlation of methylation of tumor samples with respect to the transcript expression
SR. NO. | GENE | CpG SITE/UNIT (N = 40) | SPEARMAN'S RHO (ρ) CORRELATION COEFFICIENT | Pa | LOCATION | TRANSCRIPTION FACTOR (TF) BINDING SITE |
|---|---|---|---|---|---|---|
1 | TRAIL | TRAIL 9 (-116) | -0.350 | 0.013 | Promoter | No |
2 | DR4 | DR4 10.11.12.13 (+23,+25,+28,+32) | 0.335 | 0.017 | 5'UTR | GBF2 |
3 | DR4 | DR4 7 (+108) | -0.311 | 0.025 | 5'UTR | No |
4 | CASP8 | CASP8 5 (+571) | -0.271 | 0.046 | Int 1-2 | No |
5 | CYCS | CYCS 36.37 (+241,+243) | 0.266 | 0.048 | Int 1-2 | Sp1 |
6 | ATM | ATM 1 (-369) | -0.270 | 0.046 | Promoter | No |
7 | ATM | ATM 7.8 (-314,-310) | -0.291 | 0.034 | Promoter | No |
8 | CHEK2 | CHEK2 3.4 (-396,-393) | -0.281 | 0.040 | Promoter | Sp1 |
9 | BRCA1 | BRCA1 8 (-314) | -0.300 | 0.030 | Promoter | No |
10 | BRCA1 | BRCA1 16 (-251) | -0.410 | 0.004 | Promoter | No |
11 | BRCA2 | BRCA2 44 (-101) | -0.288 | 0.036 | Promoter | Sp1 |
12 | BRCA2 | BRCA2 15.16.17 (+133,+136,+138) | -0.318 | 0.023 | 5'UTR | ER, Sp1 |