EBV-positive Hodgkin lymphoma is associated with suppression of p21cip1/waf1 and a worse prognosis

Table 1 Genes concordantly down- or up-regulated by EBER1 in KMH2 & L428

Unigene	Gene Title	K9	KE	L9	LE	Z_K	Z_L	Z_K*Z_L
Top 10 down-regulated genes
Hs.326035	Early growth response 1	379	110	3992	437	-3.8	-6.1	23.2
Hs.370771	Cyclin-dependent kinase inhibitor 1A (p21, Cip1)	2260	1164	613	18	-2.5	-7.6	19.4
Hs.440366	Similar to sirtuin 5 isoform 2; sir2-like 5	340	93	1416	201	-3.9	-4.7	18.5
Hs.56382	Hexamthylene bis-acetamide inducible 2	208	54	316	24	-3.4	-5.3	18.1
Hs.3210	Renin	483	21	93	20	-7.8	-2.2	17.0
Hs.143757	Similar to zinc finger protein 111	450	123	258	42	-4.1	-3.7	15.1
Hs.199877	Copine IV	454	154	2186	449	-3.6	-4.1	14.7
Hs.501778	Tripartite motif-containing 22	1200	606	554	47	-2.7	-5.4	14.5
Hs.349110	Hepatocyte growth factor-like	184	50	317	50	-3.2	-3.8	12.4
Hs.129867	Calcium and integrin binding family member 2	150	52	213	15	-2.6	-4.8	12.2
Top 10 up-regulated genes
Hs.292788	Homo sapiens, clone IMAGE:5189562, mRNA	10	167	22	180	3.7	4.9	18.1
Hs.147434	TRAF3 interacting protein 3	175	605	446	3676	2.8	6.4	17.9
Hs.550344	CDNA FLJ32691 fis, clone TESTI2000221	25	185	66	250	3.9	3.9	15.4
Hs.163914	Hypothetical protein DKFZp313G1735	14	138	15	160	3.2	4.6	14.8
Hs.154510	Chr 2 open reading frame 4///Carbonyl reductase 3	15	97	11	244	2.3	6.2	14.2
Hs.247831	Myosin light chain 2, precursor lymphocyte-specific	77	384	82	308	3.5	4.0	14.0
Hs.268939	Matrin 3	254	698	18	219	2.3	5.8	13.1
Hs.515011	SMAD specific E3 ubiquitin protein ligase 2	67	232	114	580	2.7	4.8	13.0
Hs.512709	Troponin I type 3 (cardiac)	34	206	31	114	3.9	3.1	12.1
Hs.530863	CASK interacting protein 1	19	126	35	162	2.9	4.0	11.8

From left to right, the columns show the UniGene number, the gene title, the gene symbol, the levels of the transcripts in K9, KE, L9, and LE, the z-score (Z_K) for the comparison between K9 & KE, the z-score (Z_L) between L9 & LE, and the product of Z_K *Z_L.

ISSN: 1476-4598