Figure 8
From: VEGF121b and VEGF165b are weakly angiogenic isoforms of VEGF-A
VEGF xxx b protein expression is increased in human breast cancer samples in comparison to healthy mammary glands. VEGF protein levels in breast cancer samples and healthy mammary glands were analyzed in a Tissue Microarray (TMA) by immunohistochemistry using an antibody raised specifically against exon 8b (A) and an anti-total VEGF-A antibody (B). The levels of both VEGFxxxb (C) and total VEGF-A (D) are higher in the breast cancer samples compared to normal breast tissues (NBT). Differences reach statistical significance when comparing normal breast glands with the Intraductal Carcinoma (IDC) subtype (p < 0.05) for both total VEGF and VEGFxxxb. Examples of staining include papillary carcinoma (Pap), phyllodes (Phy), infiltrating lobular carcinomas (ILC), and ductal carcinoma in situ (DCIS).