Taxol-resistant cells are more sensitive to glycolysis inhibitor oxamate. A, MDA-435 and 435TR1 cells were treated with various concentrations of oxamate for 48 hrs, then LDH activity was detected. Data are shown as the percentage of LDH activity inhibition detected in cells treated without oxamate. B, MDA-435 and 435TR1 were treated with various concentrations of oxamate for 48 hrs. Then the cell viability was detected using a MTS reagent. Data are presented as the percentage of viability inhibition measured in cells treated without oxamate. Columns, mean of three independent experiments; bars, SE. *, P < 0.05. **, P < 0.01.