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Figure 3 | Molecular Cancer

Figure 3

From: Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation

Figure 3

The effect of pentamidine on ATM/ATR/DNA-PK-dependent phosphorylation. (A) Pentamidine did not disturb ATM-dependent phosphorylation. MRC5SV cells were irradiated by 5 Gy of γ-ray with or without pre-treatment of pentamidine (0.5 mM, 30 minutes). These cells were harvested at 0.5 hour after IR and analyzed by Western blot using indicated antibodies. (B) Pentamidine did not disturb ATR or DNA-PK-dependent phosphorylation. MRC5SV were irradiated by 5 Gy of γ-ray with or without pre-treatment of pentamidine (0.5 mM, 1 hour). These cells were harvested at 0.5 hour after IR and analyzed by Western blot using indicated antibodies.

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Molecular Cancer

ISSN: 1476-4598