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Figure 1 | Molecular Cancer

Figure 1

From: Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo

Figure 1

Vorinostat decreases the growth and colony forming ability of MES-SA cells in vitro. (a) Dose response curve for MES-SA cells treated with five different vorinostat concentrations over three time periods. Cell proliferation was measured by using [3H]thymidine uptake assay. Results are expressed as percentage inhibition of [3H]thymidine incorporation upon vorinostat treatment and normalized to untreated cells. (b) MES-SA cells were treated with 3 μM vorinostat for 24, 48 and 72 hours. Vorinostat induced a strong decrement in the number of treated cells in comparison to untreated control cells. (c) The ability of colony formation was drastically reduced in vorinostat-treated MES-SA cells already after 24 hours and continued to decrease in a time-dependent manner.

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Molecular Cancer

ISSN: 1476-4598