The effect of Klf5 heterozygosity on intestinal tumor burden in ApcMin/ KRASV12mutant mice at 12 weeks of age. Tumor burden is plotted as the number of tumors per mouse on the Y-axis. Tumor number from each individual mouse is shown as an open symbol, while the averages of the tumor numbers are represented as black bars. (A) Tumor burden in the small intestine; N = 8 for each genotype and **, P < 0.01. (B) Tumor burden in the colon; N = 8 for each genotype. (C) Overall tumor burden including both the small intestine and colon; N = 8 for each genotype and **, P < 0.01.