Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma

Table 4 Cox regression analysis of risk factors for death due to recurrence in 82 HCC patients

Variables	HR	95 % confidence interval		P- value
Sex	2.469	0.850	7.173	0.097
Age	0.863	0.430	1.732	0.679
HBV infection	0.665	0.250	1.767	0.413
TNM stage	4.089	1.864	8.972	0.000^b
Liver function(Child grade) A		0.038
B	2.092	0.846	5.174	0.110
C	4.185	1.162	15.074	0.029^a
Alcohol consumption	4.576	1.854	11.293	0.001^b

HR: Hazard ratio; Sex: female vs male (HR: 2.469); Age: >50 yr vs ≤50 (HR: 0.863); HBV infection: positive vs negative (HR: 0.665); TNM: III-IV vs I-II (HR: 4.089); Liver function (Child grade): B vs A (HR: 2.092), C vs A (HR: 4.185); Alcohol consumption: alcoholic vs nonalcoholic (HR: 4.576); ^a P < 0.05; ^b P < 0.01.

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