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Table 1 Proteins regulated upon OTUB1 knockdown in LNCaP-FGC cells

From: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo

Gene name Uniprot Log2(siOTUB1_1/siControl) Log2(siOTUB1_2/siControl) Mean (SD)
ACPP P15309 −7.23 −3.08 −5.15 (2.94)
ACTA2 P62736 −3.52 −5.65 −4.58 (1.51)
SHROOM3 Q8TF72 −3.75 −3.24 −3.49 (0.36)
KLK3 P07288 −3.52 −2.72 −3.12 (0.57)
TAGLN Q01995 −2.44 −3.36 −2.9 (0.65)
DES P17661 −3.69 −1.95 −2.82 (1.23)
KPRP Q5T749 −2.33 −2.75 −2.54 (0.3)
ST14 Q9Y5Y6 −1.03 −3.95 −2.49 (2.07)
DCD P81605 −2.60 −2.34 −2.47 (0.19)
CASP14 P31944 −3.23 −1.44 −2.34 (1.27)
STAM Q92783 −1.36 −2.18 −1.77 (0.58)
ACTC1 P68032 −1.05 −2.36 −1.7 (0.93)
ANXA2 P07355 −1.17 −2.17 −1.67 (0.71)
HSPB1 P04792 −1.20 −1.91 −1.56 (0.5)
DTNB O60941 −1.57 −1.55 −1.56 (0.02)
SNX2 O60749 −0.82 −1.84 −1.33 (0.72)
BLMH Q13867 −1.44 −1.09 −1.27 (0.25)
MICAL1 Q8TDZ2 −1.02 −1.43 −1.23 (0.29)
WDR7 Q9Y4E6 −1.17 −1.26 −1.21 (0.06)
MALT1 Q9UDY8 −1.28 −0.99 −1.13 (0.2)
RAB8A P61006 −0.75 −1.23 −0.99 (0.34)
NOC2L Q9Y3T9 −1.04 −0.89 −0.96 (0.1)
ARHGAP35 Q9NRY4 −1.19 −0.73 −0.96 (0.32)
UBE2K P61086 −1.09 −0.81 −0.95 (0.2)
USP39 Q53GS9 −1.19 −0.69 −0.94 (0.36)
HMGCS2 P54868 −0.72 −1.12 −0.92 (0.28)
QSOX1 O00391 −0.92 −0.89 −0.9 (0.02)
TOR1AIP1 Q5JTV8 −0.75 −0.91 −0.83 (0.11)
ADAM9 Q13443 −0.86 −0.73 −0.79 (0.09)
LAMC1 P11047 −0.77 −0.80 −0.79 (0.02)
NUP88 Q99567 −0.71 −0.86 −0.79 (0.1)
YWHAB P31946 −0.68 −0.73 −0.71 (0.03)
NDRG1 Q92597 −0.65 −0.75 −0.7 (0.07)
FAM160B1 Q5W0V3 −0.66 −0.66 −0.66 (0)
DBR1 Q9UK59 0.65 0.59 0.62 (0.05)
SLC4A2 P04920 0.89 0.75 0.82 (0.1)
POLA1 P09884 0.69 1.14 0.91 (0.32)
DDX42 Q86XP3 0.92 1.13 1.02 (0.15)
TTN Q8WZ42 1.50 1.22 1.36 (0.2)
PTGFRN Q9P2B2 2.04 1.66 1.85 (0.27)
  1. Proteins showing changes in expression after OTUB1 knockdown using two different siRNA, compared to control siRNA transfected LNCaP-FGC cells. Androgen regulated proteins are highlighted. Fold changes are shown as log2 of the ratio between the intensity of the proteins in the siRNA transfected and control siRNA transfected cells. Mean values and Standard deviation (SD) for both experiments are shown on the right column.