Figure 6
From: miR-17 deregulates a core RUNX1-miRNA mechanism of CBF acute myeloid leukemia
The extent of KIT expression per se delays myeloid differentiation in cells with functional RUNX1. (A) CD117 cytofluorimetric analysis showing ectopic KIT expression in 32DKIT-Low and 32DKIT-High stable clones. (B) Growth curves showing increased proliferation of 32DKIT-Low and 32DKIT-High clones relative to the 32DEV control clone in response to different concentrations of G-CSF. (C-D) CD11b cytofluorimetric analysis shows that increasing KIT expression delays G-CSF-induced differentiation in a G-CSF dose-dependent (C) and time-dependent manner (D). See text and Additional file 4: Table S3 for statistical significance.