Figure 3
From: Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma
Expression profiles of M207 and M296 indicating a similar MAPK, but distinct cell-cycle and apoptosis response to the treatment. A) Analysis of MAPK signaling by gene expression profiles of resistant cell line M207 and the sensitive cell line M296. B) The effect of treatments on cell cycle expression profile of M207 and M296 are depicted by the heat map and the bar graph. C) Higher perturbation of apoptotic profile by the treatments in the sensitive cell line M296 in comparison with M207. For these experiments cell lines were treated with DMSO, 25 nM of MEKi, 500 nM of PRi or their combination for 24 hours before extraction of RNA for the microarray analysis.