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Table 2 Expression of pS 21 GSK3α/pS 9 GSK3β in various OTSCC and control tissue samples and their correlation with clinico-pathological parameters

From: Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression

Sl. No. Groups Total (N = 57) pS 21 GSK3α pS 9 GSK3β p-value (pS 9 GSK3β over pS 21 GSK3α )
Expression Overexpression Expression Overexpression Expression Overexpression
1 Age        
 ≤40 8 04 (50.0%) 03 (37.5%) 06 (75.0%) 04 (50.0%) NS NS
 >40 ≤ 70 42 29 (69.0%) 12 (27.9%) 37 (88.0%) 30 (71.4%) NS 0.0002
 >70 07 05 (71.4%) 03 (42.8%) 06 (85.7%) 05 (71.4%) NS NS
2 Sex        
 Male 34 22 (64.7%) 09 (26.4%) 29 (94.5%) 22 (64.7%) NS 0.0032
 Female 23 16 (69.5%) 09 (39.1%) 20 (91.3%) 17 (73.9%) NS 0.036
3 Histological grade        
 WDSCC 37 29 (78.3%) 17 (45.9%) 37 (100%) 32 (86.4%) 0.01 0.0004
 MDSCC 06 03 (50.0%) 01 (16.6%) 06 (100%) 02 (33.3%) 0.01 NS
 PDSCC 05 02 (40.0%) 00 (00.0%) 03 (60.0%) 03 (60.0%) NS NS
4 Size        
   T1-T2 44 31 (70.4%) 17 (36.1%) 41 (93.6%) 34 (77.2%) 0.01 0.0005
   T3-T4 06 04 (66.6%) 01 (16.6%) 06 (100%) 04 (66.6%) NS NS
5 Lymph nodes        
   N0 47 33 (70.2%) 18 (38.2%) 44 (93.6%) 37 (78.7%) 0.006 0.005
   N1-N3 03 02 (66.6%) 00 (100%) 03 (100%) 01 (33.3%) NS NS
6 Distant Metastasis        
   M0 50 35 (70.0%) 18 (36.0%) 47 (94.0% 38 (76.0%) 0.003 0.0001
   M1 00 00 (00.0%) 00 (00.0%) 00 (00.0%) 00 (00.0%) NA NA
7 Tissue types        
 OSCC (Tongue) 50 35 (70.0%) 18 (36.0%) 47 (94.0% 38 (76.0%) 0.003 0.0001
 Normal Tongue (Cancer adjacent) 7 03 (42.8%) 00 (00.0%) 02 (28.5%) 01 (14.2%) NS NS