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Figure 4 | Molecular Cancer

Figure 4

From: Intelectin 1 suppresses the growth, invasion and metastasis of neuroblastoma cells through up-regulation of N-myc downstream regulated gene 2

Figure 4

ITLN1 suppresses the growth, migration, and invasion of NB cells in vitro through up-regulating NDRG2. (A and E) Western blot showing the protein levels of ITLN1 [in culture supernatant (s)] and NDRG2 (in lysate) in NB cells stably transfected with empty vector (mock), ITLN1, sh-Scb, or sh-ITLN1, and those co-transfected with sh-NDRG2 or NDRG2. (B and F) Quantification of colony formation assay showing the growth potential of NB cells stably transfected with mock, ITLN1, sh-Scb, or sh-ITLN1, and those co-transfected with sh-NDRG2 or NDRG2. (Cand G) Migration of NB cells upon transfection with mock, ITLN1, NDRG2, sh-Scb, sh-ITLN1, or sh-NDRG2 depicted by scratch assay after 24 hrs. (D and H) Representation (top) and quantification (bottom) of matrigel invasion assay showing the in vitro invasion of NB cells stably transfected with mock, ITLN1, sh-Scb, or sh-ITLN1, and those co-transfected with sh-NDRG2 or NDRG2. *P < 0.01 vs. mock or sh-Scb.

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Molecular Cancer

ISSN: 1476-4598