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Figure 7 | Molecular Cancer

Figure 7

From: Sp1 and c-Myc modulate drug resistance of leukemia stem cells by regulating survivin expression through the ERK-MSK MAPK signaling pathway

Figure 7

Expression of Sp1 and c-Myc in CD34+ AML patients and correlations with survivin levels. (A) A total of 56 paired CD34+ and CD34- AML patient samples were collected. For each sample, the expression levels of Sp1 and c-Myc were determined by RT-qPCR and normalized to GAPDH as an internal control. (B) The relative expression of each sample is illustrated. The scatter dot plot shows the relative levels of Sp1 and c-Myc in CD34+ and CD34- cells from AML patients. (C-D) Correlations among survivin, Sp1, and c-Myc mRNA levels in CD34+ AML patients, as determined using RT-qPCR and Spearman’s analysis. (E-F) Correlations among survivin, Sp1, and c-Myc protein levels CD34+ AML patients (n = 56), as determined using Fisher’s exact probability test.

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Molecular Cancer

ISSN: 1476-4598