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Figure 4 | Molecular Cancer

Figure 4

From: Dichloroacetate restores drug sensitivity in paclitaxel-resistant cells by inducing citric acid accumulation

Figure 4

DCA partially inactivates P-glycoprotein activity in drug-resistant cell lines. (A) P-glycoprotein expression in A549 and A549/Taxol cells treated with 0 or 10 mM DCA for 24 h, as determined by western blotting. (B) Influence of DCA, verapamil, or DCA + verapamil on 99mTc-MIBI uptake. Verapamil was used as a positive control. (C) Influence of DCA, verapamil, or DCA + verapamilon 99mTc-MIBI excretion. (D) Influence of DCA, verapamil, or DCA + verapamilon accumulation of doxorubicin. *P < 0.05. Data are mean ± SEM of three independent experiments.

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Molecular Cancer

ISSN: 1476-4598