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Figure 1 | Molecular Cancer

Figure 1

From: SapC-DOPS nanovesicles induce Smac- and Bax-dependent apoptosis through mitochondrial activation in neuroblastomas

Figure 1

Preparation and tumor-targeting potential of SapC-DOPS in mice xenografts. A) Treatment of athymic nude mice bearing neuroblastoma (CHLA-20) xenografts with CVM-labeled SapC-DOPS (1), CVM-DOPS (2) or SapC-CVM (3). Animals were imaged 24 h after injection with exposure time of 1 s. Saposin C, 4.2 mg/kg; dioleoylphosphatidylserine, 2 mg/kg; CellVue Maroon, 6 μmol. B) Evaluation of tumor burden in SapC-DOPS treated mice xenografts. Mice xenografts (n = 15) were treated with five intratumoral injections of SapC-DOPS (SapC 4 mg/kg, DOPS 2 mg/kg) or PBS every 3 days and followed for tumor growth. C) Histological examination of the neuroblastoma tumor tissue in mice after intratumoral injection of DOPS and SapC-DOPS. Original magnification: 1000x. D) Evaluation of apoptosis by TUNEL staining (arrows) in DOPS- and SapC-DOPS treated tumors. Original magnification: 40x.

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Molecular Cancer

ISSN: 1476-4598