Figure 7

Big picture summary of the effects of MG-specific PPARγ loss. PPARγ-MG KO mice have decreased serum levels of proinflammatory and chemotactic cytokines (IL-4, eotaxin, GM-CSF, IFN-γ, and MIP-1α) which may, in part, contribute to their decreased susceptibility to DMBA Only-mediated carcinogenesis compared to PPARγ-WTs. Activation of PPARγ in MG cells suppresses breast tumourigenesis in PPARγ-WT mice by increasing BRCA1 and suppressing VEGF and Cox-2 expression, effectively rescuing PPARγ-WT mice from breast tumour progression. In MG cells lacking PPARγ expression, DMBA-induced breast tumour progression is enhanced by cotreatment with a PPARγ activator, due to PPARγ-independent activation of Cox-2.