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Figure 4 | Molecular Cancer

Figure 4

From: FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance

Figure 4

Electronegative potentials influence the affinity of the Position 7-substituted FL118 analogues for ABCG2 binding. A, structures of FL118 analogues with B ring substitutions. B, correlation between electronegativity of chemical groups (χ, Pauling units, calculated using the method of Huheey) and the ratio of EC50 of drug alone / EC50 drug + Ko143.

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Molecular Cancer

ISSN: 1476-4598