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Figure 5 | Molecular Cancer

Figure 5

From: KLF5 inhibits angiogenesis in PTEN-deficient prostate cancer by attenuating AKT activation and subsequent HIF1α accumulation

Figure 5

KLF5 decreases protein expression of HIF1α and secretion of pro-angiogenic factors. In PC-3 and DU 145 cells with stable knockdown (A), ectopic expression (B), RNAi-mediated transient knockdown (C), or adenovirus-mediated overexpression (D) of KLF5, HIF1α protein was detected by Western blotting whereas secretory pro-angiogenic factors PDGF-BB and VEGF in the conditioned media were detected by ELISA. shK1 and shK2 indicate 2 lentiviral shRNAs targeting KLF5 (sh36 and sh37), siK represents siRNA targeting KLF5 (siKLF5), and Ad-K represents adenovirus expressing KLF5. *, P < 0.05; **, P < 0.01; N.S., not statistically significant.

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Molecular Cancer

ISSN: 1476-4598