Figure 2

High expression of DLX4 is associated with increased iNOS expression in clinical specimens of ovarian cancer. Cases from the Australian Ovarian Cancer Group Study [23] (GSE9891, n = 285) were stratified according to DLX4 expression in tumors, where DLX4 mRNA levels were defined as High (≥ upper quartile) and Low (≤ lower quartile). Significance of differences in NOS1, NOS2 and NOS3 mRNA levels (log2 scale) between upper and lower quartile sub-groups was evaluated by Mann–Whitney U-test. The same analysis was performed for cases from the Japanese Serous Ovarian Cancer Group Study [24] (GSE32062, n = 260).