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Figure 4 | Molecular Cancer

Figure 4

From: Restin suppressed epithelial-mesenchymal transition and tumor metastasis in breast cancer cells through upregulating mir-200a/b expression via association with p73

Figure 4

Restin overexpression inhibited lung metastasis in vivo. (A) The volume of primary tumors was measured after the transplantation of Control and Restin overexpressed MDA-MB-231 cells. 1 × 105 MDA-MB-231 cells were subcutaneously injected into the mammary fat pad of immunocompromised NOD/SCID mice (n = 5). Tumor growth was monitored every 4 days. Data were shown as mean size ± S.M. of tumors in five mice per cell line. Animal experiments were repeated three times. (B) Xenograft tumor size from NOD/SCID mice grafted with Control and Restin-overexpressed cells. (C) The metastatic nodules in the lungs were counted following the orthotopic transplantation of Control and Restin overexpressed MDA-MB-231 cells. Values were expressed as means ± S.M. in five mice. * p < 0.05 vs Control. (D) Representative HE staining of lung metastases. Arrows indicate micrometastases.

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Molecular Cancer

ISSN: 1476-4598