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Fig. 7 | Molecular Cancer

Fig. 7

From: NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7

Fig. 7

Molecular switch from NOX1 to NOX2 induces invasive phenotype change in colon cancer cells. NOX2-derived ROS activates MAPKs, p38, ERK, and JNK with deactivation of AMPK. P38 activates NF-κB, which induces NOX2, p47phox, and p67phox. At the same time, p38, ERK, and JNK activate AP-1, which up-regulates MMP-7 gene expression in cooperation with NF-κB

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Molecular Cancer

ISSN: 1476-4598