Table 2 Multivariate analysis of overall and progression-free survival for HNSCC patients of the combined cohort

KLK6

low vs. high¹

2.793 (1.498–5.209)

0.001

2.236 (1.291–3.873)

0.004

Age [years]

<58.62¹ vs. ≥58.62

1.588 (0.892–2.825)

0.116

1.359 (0.811–2.277)

0.244

Gender

male¹ vs. female

0.571 (0.268–1.219)

0.148

0.567 (0.281–1.143)

0.112

Clinical stage

I/II¹ vs. III/IV

2.333 (0.892–6.104)

0.084

1.621 (0.724–3.629)

0.240

Pathological grade

G1/2¹ vs. G3

0.811 (0.431–1.527)

0.517

1.135 (0.648–1.987)

0.658

smoking

non-smoker¹ vs. smoker²

1.701 (0.602–4.808)

0.317

2.831 (1.013–7.912)

0.047

Alcohol consumption

non-drinker¹ vs. drinker³

0.911 (0.343–2.418)

0.852

1.056 (0.440–2.535)

0.903