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Table 1 P-cadherin expression in primary tumours and its relevance in malignancy. The tumour promoting or tumour suppressive effects associated with P-cadherin expression is dependent on the cellular and tissue context

From: P-cadherin and the journey to cancer metastasis

Malignancy Expression in neoplastic tissue/cells in comparison to normal tissue/cells Behaviour References
Breast cancer Up-regulation Tumour promoting Paredes et al., 2005 [53]
Gastric cancer Up-regulation Tumour promoting Shimoyama et al., 1991 [54]
Endometrial cancer Up-regulation Tumour promoting Moreno-Bueno et al., 2003 [55] Stefansson et al., 2004 [56]
Ovarian cancer Up-regulation Tumour promoting Patel et al., 2003 [57]
Pancreatic cancer Up-regulation Tumour promoting Taniuchi et al., 2005 [58]
Basocellular and squamous carcinoma of the skin Up-regulation Tumour promoting Wakita et al.,1998 [59] Hardy et al., 2002 [60]
Cholangiocarcinoma Up-regulation Tumour promoting Obama K et al., 2005 [111]
Colorectal carcinoma Up-regulation Tumour promoting Hardy et al., 2002 [60] Imai et al., 2008 [9] Sun et al., 2011 [71]
  Down-regulation Tumour suppressive Van Marck et al., 2011 [39]
Bladder cancer Up-regulation Tumour promoting Wang et al., 2014 [41]
  Down-regulation Tumour suppressive Mandeville et al., 2008 [38] Van Marck et al., 2011 [39]
Prostate cancer Up-regulation Tumour promoting Arenas et al., 2000 [42]
  Down-regulation Tumour suppressive Jarrard et al., 1997 [40]
Melanoma Down-regulation Tumour suppressive Fenouille et al., 2012 [92] Van Marck et al., 2005 [43] Jacobs et al., 2011 [44]
Non small cell lung cancer Down-regulation Tumour suppressive Smythe et al., 1999 [45]
Oral squamous cell carcinoma Down-regulation Tumour suppressive Lo Muzio et al., 2004 [47] Muñoz-Guerra et al., 2005 [48]
Hepatocellular carcinoma Down-regulation Tumour suppressive Bauer R et al., 2014 [52]