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Fig. 6 | Molecular Cancer

Fig. 6

From: Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine

Fig. 6

OPN/LC3/ALDH1 coexpression and OPN/CD44/CD133 coexpression are associated with poor patient survival. a Pancreatic cancer tissues were triplestained for OPN (blue), LC3 (red), and ALDH1 (green) (upper panel), and triplestained for OPN (blue), CD44 (red), and CD133 (green) (lower panel). The staining was visualized by confocal microscopy. Magnification: 400×, scale bar: 20 μm. b Immunofluorescence staining of OPN, LC3, ALDH1, CD44, and CD133 was performed in TMAs. OPN expression was positively correlated with LC3/ALDH1 coexpression (R = 0.354, P < 0.001) and CD44/CD133 coexpression (R = 0.211, P = 0.042). c Kaplan–Meier analysis showed that high levels of OPN/LC3/ALDH1 were associated with worse OS and DFS (P = 0.029 and P = 0.009). d Kaplan–Meier survival curves showed that high levels of OPN/CD44/CD133 were associated with worse OS and DFS (P < 0.001 and P < 0.001)

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Molecular Cancer

ISSN: 1476-4598