Fig. 2
H19 in proliferation and in response to hypoxic stress. Hypoxia induces H19 expression under hypoxic stress in p53 mutated cells, in which HIF1α, which is essential to H19 upregulation, as well as H19 itself, are not repressed by P53. Since hypoxia is a mutagenic condition per se, it can also induce p53 mutations and cause the H19 response. H19 promotes cell cycle progression through Rb suppression by its miR-675 or by p57kip2 (CDKN1C) suppression or c-Myc activation