Table 2 Inhibitors of DDX3Original table attached in the e-mail.  Please use this  for the paper. Font and Bold features should be maintained

1a

2

2-OH

5.4

1b

2

2-OH

0.3

1c

2

2-OH

0.5

1d

2

2-OH

1.0

[98]

1e

2

2-OH

0.1

1f

2

2-Cl

3.9

1 g

2

2-COOH

0.4

1 h

2

2-COOH

2.0

2a

2

2-OH

4.2

[98]

2b

2

2-OH

4.3

3

2

2-OH

28

[98]

Structure for modification

Cmpd#

n

R1

R2

R3

Ki [μM]

4a

0

NH-Ph

H

-

0.4

4b

0

morpholinyl

3-Cl

-

1.6

[98]

4c

1

morpholinyl

3-Cl

-

2.9

4d

1

NEt₂

H

-

0.1

5a

0

NH-Ph

H

Ph(4-NHCOCH₃)

0.3

5b

1

NH-Ph

H

Ph(4-NHCOCH₃)

0.5

5c

0

morpholinyl

H

Ph(4-NHCOCH₃)

2.2

5d

0

morpholinyl

F

Ph(2-OH)

0.7

5e

1

morpholinyl

H

Ph(2-OH)

0.6

[98]

5f

1

morpholinyl

H

Ph(2-OH, 5-Cl)

1.9

5 g

1

morpholinyl

H

Ph(2-OH, 3-NO₂)

4.0

5 h

0

morpholinyl

4-F

Ph(2-OH)

0.4

5i

0

NH-Ph(4-F)

4-F

Ph(2-OH)

0.1

5j

0

morpholinyl

4-F

2-methyl-indol-3-yl

0.2

6a

0

morpholinyl

4-F

Ph(2-Cl, 4-NO₂)

0.3

6b

0

piperidinyl

H

Ph(4-Cl)

0.4

[98]

Structure modification

[47]

[104]