Fig. 7

Effects of macrophage depletion on TQ-induction of ascites. a Schematic of weekly clodronate/empty liposome (EL) and thrice weekly vehicle or 20 mg/kg TQ treatment for 30 days. b Clodronate depletes mononuclear cells in ascites collected from mice treated weekly with empty liposomes (EL), liposomal-conjugated clodronate (Clod), thrice weekly with TQ (20 mg/kg) and empty liposomes and TQ and clodronate for 30 days, as quantified in differential cell counts of H&E-stained cytospin slides. c Volume of ascites, number of peritoneal implants and mesenteric tumor mass in mice treated with clodronate/empty liposome (EL) and thrice weekly vehicle or 20 mg/kg TQ treatment for 30 days. *p < 0.01 compared to vehicle; #p < 0.01 compared to TQ and empty liposome treatment alone, both Mann–Whitney test