Skip to main content
Fig. 5 | Molecular Cancer

Fig. 5

From: Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells

Fig. 5

P2 receptors regulate the migratory properties of lung cancer cells. Panel a The effect of iso-PPADS on the migration of A549 (left) and HTB177 (right) cells across Transwell membranes in response to adenosine. HGF (10 ng/ml) was used as positive control. The experiment was done three times. *p < 0.05. Panel b. The effect of the P2X7R inhibitor A438079 on the migration of HTB177 (left) and HTB183 (right) cells acros Transwell membrane in response to ATP. The experiment was done three times. *p < 0.05. Panel c. The effect of the P2X7 inhibitor A438079 on intracellular calcium measurements in lung cancer cell lines in response to 100 μM ATP. Analysis was performed at least 3 times in triplicates *p < 0.05. Panel d. The effect of pretreatment of cells with ivermectin (10 μM) on Transwell membrane migration in response to ATP. The experiment was done three times. *p < 0.05

Back to article page

Molecular Cancer

ISSN: 1476-4598