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Fig. 4 | Molecular Cancer

Fig. 4

From: The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells

Fig. 4

BzATP has similar effects as ATP stimulation in PDAC and HPDE. The BrdU incorporation data were normalized to 1 % serum control (100), and all cell lines were normalized with respect to the control. The black line and filled symbols show the effect of different concentration of BzATP (10 μM, 100 μM and 1 mM) on BrdU incorporation in HPDE cells after 60 h. The colour lines/symbols show the effect of BzATP on the different PDAC cell lines. The graph shows data from three to six experiments (mean ± SEM), each run was carried out in triplicates. At 100 μM BzATP, there were significant differences P < 0.05 (*) between control and treatment in BxPC-3 and P < 0.001 (**) in HPDE and AsPC-1 cells. At 1 mM BzATP there was significant inhibition P < 0.001 (**) of BrdU incorporation in all cell lines compared their respective controls

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