Fig. 7

Non-overlapping interaction patterns and protein interaction networks. a Data from a subset of the 7df3 network displayed in more detail to highlight an important feature of the network; that functional co-operativity is limited to selected enhancer combinations. b Further examples of simple non-overlapping sub-networks. c Overlay of the ‘functional connectome’ on a Wnt PIN. Twenty protein communities (coloured nodes with grey links indicating protein interaction) were identified by modularity maximisation using the Louvain method. To guide the eye the layout algorithm emphasises these communities and only positive functional connections with a link weight greater than 1.5 are shown with opacity reflecting the strength of interaction