Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma

Table 1 Multivariate Cox regression analysis for OS and PFS

	Overall survival			Progression-free survival
Risk factor	HR	95 % CI	p-value	HR	95 % CI	p-value
Gender female vs male	1.016	0.47–2.19	0.967	0.960	0.48–1.94	0.911
Age	0.966	0.49–1.89	0.921	0.862	0.45–1.64	0.650
>57 vs ≤57	0.966	0.49–1.89	0.921	0.862	0.45–1.64	0.650
Clinical stage	5.699	1.35–24.09	0.018	3.353	1.15–9.77	0.027
III/IV vs I/II	5.699	1.35–24.09	0.018	3.353	1.15–9.77	0.027
Tobacco current vs. never	0.687	0.15–3.15	0.629	0.431	0.12–1.49	0.184
Tobacco former vs. never	1.261	0.23–6.88	0.789	0.877	0.21–3.60	0.856
Alcohol current vs never	0.786	0.28–2.18	0.644	1.261	0.50–3.16	0.621
Therapy¹ radiochemo vs surgery	0.953	0.46–1.98	0.897	0.798	0.40–1.60	0.524
HPV status² related vs non-related	0.404	0.17–0.96	0.041	0.305	0.13–0.70	0.005
Subgroup	0.303	0.14–0.63	0.002	0.395	0.20–0.77	0.007
ALDH1A2^highCRABP2^high vs others	0.303	0.14–0.63	0.002	0.395	0.20–0.77	0.007

HR = Hazard ratio, CI = confidence interval, ¹ first line treatment, ² related = viral DNA ⁺ RNA ⁺ , non-related = viral DNA ⁺ RNA ⁻ or viral DNA ⁻ according to [32]

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