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Fig. 7 | Molecular Cancer

Fig. 7

From: MiR-214 increases the sensitivity of breast cancer cells to tamoxifen and fulvestrant through inhibition of autophagy

Fig. 7

A summary of the relationships between miR-214, UCP2, beclin-1, LC3-II, Bax, Caspase-9, PARP, and PI3K-Akt-mTOR after TAM/FUL treatment. TAM/FUL treatment results in autophagy as well as apoptosis. MiR-214 increased the sensitivity of breast cancer cells to the 4-OHT/FUL-induced apoptosis through inhibition of autophagy. UCP2 was identified to be a direct target of miR-214. Overexpression of UCP2 inhibited TAM/FUL-induced cell apotosis by increasing autophagy possibly through activation of the PI3K-Akt-mTOR signaling pathway, thereby contributing to endocrine resistance

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Molecular Cancer

ISSN: 1476-4598