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Table 1 The Zn transporting network is differentially expressed between breast cancer subtypes

From: Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer

 

Breast tumor*

     

Cell line*

Cell line**

 

Microarray

Microarray

PCR

Genea

Basal vs ER HG

Basal vs ER LG

Basal vs HER2

ER HG vs ER LG

ER HG vs HER2

ER LG vs HER2

Basal vs Luminal

Basal vs Luminal

MT1E

1.8

1.5

1.8

-

-

-

3.2

Basal only

MT1G

1.5

1.5

-

-

-

-

1.9

 

MT1H

1.6

1.6

-

-

-

-

2.2

 

MT1×

2.0

1.5

-

-

−1.6

-

2.5

 

MT2A

1.3

1.4

-

-

−1.3

−1.4

2.1

 

SLC30A1

-

-

-

-

-

1.2

-

-

SLC30A2

-

-

-

-

-

-

-

−3.9

SLC30A4

-

-

-

-

-

-

-

-

SLC30A5

−1.2

−1.2

-

-

-

-

−1.4

−13.6

SLC30A6

1.2

1.2

-

-

-

-

-

−8.5

SLC30A8

−3.1

-

-

-

2.2

-

-

-

SLC30A9

−1.3

−1.3

-

-

-

-

-

5.0

SLC30A10

-

-

-

-

-

-

-

−46.4

SLC39A1

1.3

1.2

-

-

-

-

-

-

SLC39A2

1.2

1.1

-

-

-

-

-

18.0

SLC39A4

1.9

2.2

-

-

-

−1.5

-

−60.0

SLC39A6

−4.1

−3.2

-

-

3.3

2.6

−2.3

-

SLC39A7

-

-

-

-

-

−1.4

-

-

SLC39A8

-

2.3

-

1.9

-

-

2.3

3.0

SLC39A9

−1.8

−1.8

−1.5

-

-

1.2

−1.8

-

SLC39A11

−1.8

−1.6

−2.2

-

-

−1.4

−2.5

−5.7

SLC39A12

1.2

1.2

-

-

-

-

-

-

SLC39A14

1.8

1.4

2.1

-

-

1.4

2.3

-

  1. ER HG estrogen receptor positive, high grade, ER LG estrogen receptor positive, low grade
  2. *Numbers represent mean fold difference between subtypes analyzed by independent pairwise comparison, p < 0.05
  3. **Numbers represent mean fold difference between MDA-MB-231 (basal-like) and T47D (luminal) cells analyzed by Student’s t-test, p < 0.05
  4. aOnly genes that are significantly differentially expressed are indicated
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Molecular Cancer

ISSN: 1476-4598