Fig. 2

a Schematic representation of the MLL3 protein and distribution of mutations found in ATL patients. Nonsense and missense mutations found in ATL patients are shown in red and blue, respectively. b Chromatogram of the sequence of MLL3 from normal PBMC DNA (top) and MLL3 from ATL DNA with amino acid 904 nonsense mutation (bottom). c Alignment of ATL patient DNA KOE with MLL3 demonstrates the presence of a stop codon TGA in position 904. SNPs identifying the MLL3 sequence (different from Chr13) are labeled in red