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Fig. 5 | Molecular Cancer

Fig. 5

From: Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population

Fig. 5

U0126 inhibits the growth of rhabospheres-derived xenografts. a FACS analysis of CD133 positive cells in rhabdosphere cells (SC-mSPH) before subcutaneously injection. b-e Mice bearing tumor xenografts derived from rhabdosphere cells were treated with vehicle (group: SC-mSPH) or with U0126 by intraperitoneal injection at 25 μmol/kg/mouse (group: SC-mSPH, U0126 i.p.); tumor size was assessed every 4 days. b Mean time of tumor progression. c Analysis of tumor progression by Kaplan-Meier curves. d Hazard Ratio (HR) with comparison of growth curves by Logrank test. e tumor volume and tumor weight at the end of the experiment (4 weeks of treatment). Bars represent mean ± S.D. Statistical significance is indicated (*p < 0.05)

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