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Fig. 2 | Molecular Cancer

Fig. 2

From: ERK mediated upregulation of death receptor 5 overcomes the lack of p53 functionality in the diaminothiazole DAT1 induced apoptosis in colon cancer models: efficiency of DAT1 in Ras-Raf mutated cells

Fig. 2

DR5 induction by DAT1 in p53 mutated cell lines a. HCT116 p53 −/−, SW620, SW480 and HT29 were treated with DAT1 at ~1.5 X IC50 concentration for the indicated time periods and DR5 activation was checked by western blotting. b. HCT116 p53 −/− was treated with DAT1 and western blotting was performed using DR4 and Fas antibodies

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Molecular Cancer

ISSN: 1476-4598