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Fig. 2 | Molecular Cancer

Fig. 2

From: Inhibition of BMP and of TGFβ receptors downregulates expression of XIAP and TAK1 leading to lung cancer cell death

Fig. 2

Inhibition of BMP signaling activates TAK1 and Smad2. a, b Western Blot analysis of H1299 tumor xenografts treated with DMH2 for 24 h and 9 days showing inhibitors increase expression of pSmad2 and pTAK1. (c, d) Western blot analysis of H1299 and A549 cells treated with increasing doses of DMH2 in vitro for 48 h showing an increase followed by a decrease in expression pTAK1 and pSmad2 (n = 4). (e) Western blot of knockdown of alk2 and alk3 or alk2, alk3, and alk6 showing an increase in pSmad2 and Smad2 expression (n = 2). (f) Western blot of cells treated with DMH1 in vitro for 48 h (n = 3)

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Molecular Cancer

ISSN: 1476-4598